Role of calprotectin in cardiometabolic diseases

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Publikace nespadá pod Ekonomicko-správní fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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KRUŽLIAK Peter NOVÁK Jan NOVÁK Miroslav FODOR George J.

Rok publikování 2014
Druh Článek v odborném periodiku
Časopis / Zdroj Cytokine & Growth Factor Reviews
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://www.sciencedirect.com/science/article/pii/S1359610114000069
Doi http://dx.doi.org/10.1016/j.cytogfr.2014.01.005
Obor Fyziologie
Klíčová slova Calprotectin; Cardiovascular diseases; Metabolic diseases; Obesity; Myocardial infarction
Popis Calprotectin represents an interesting peptide known to be involved in the pathophysiology of various inflammatory processes. Being secreted from activated neutrophils and monocytes under various conditions, it can also be found in the extracellular fluids and serve as a biomarker of ongoing inflammation, which property is currently used in the monitoring of inflammatory bowel diseases. Recent studies, however, suggest that calprotectin could serve as an important prognostic factor for cardiovascular and cardiometabolic diseases, since these are occurring on the basis of low-grade chronic inflammation. We assume that calprotectin may represent a useful marker in predicting the course of atherosclerotic process, coronary artery disease and acute coronary syndromes. Our review is focused on the importance of calprotectin in the diagnosis and prognostic stratification in the field of cardiometabolic risk.
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