Informace o projektu
Národní centrum lékařské genomiky
(NCLG)
- Kód projektu
- LM2015091
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Spolupracující organizace
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Univerzita Karlova
- Odpovědná osoba doc. Ing. Stanislav Kmoch, CSc.
Fakultní nemocnice Plzeň
Fakultní nemocnice v Motole
Fakultní nemocnice Brno
Všeobecná fakultní nemocnice v Praze - Praha 2
National Centre of Medical Genomics (NCMG) is the only research infrastructure in the Roadmap for Large Research, Development and Innovation Infrastructures of the Czech Republic focused on medical genomics. Its existence and support must be therefore one of national priorities. Local (national) genomic infrastructure is the only way how we can unite genomic experts, clinicians, scientist, patients and industry to study, identify and understand causes of individual and population specific diseases. Interdisciplinary collaboration will increase competitiveness of Czech biomedical science and our recent results clearly document, that this approach leads to significant discoveries (e.g. identification of causal genes and elucidation of molecular basis of > 20 human genetic diseases, leukemia, aspergillosis, inherited neurodegenerative and neuromuscular diseases, skin diseases and metabolics diseases), may attract foreign investigators to use the expertize and may have economic impact (new diagnostic products introduced on the market thanks to collaboration of MU and company Generi BioTech). Infrastructure is also important for education and training of new generation of scientists, computing specialists, bioinformaticians, statisticians, instrument operators, clinical genomicists and clinicians. All participating groups are involved in pregraduate and postgraduate education as well as in organization of specialised training programs and courses and organisation of workshops and symposia, e.g. Next-gen Sequencing Technologies and Applications organized in 2013 in Brno.
Publikace
Počet publikací: 36
2020
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Genome sequences of two Antarctic strains of Pseudomonas prosekii: insights into adaptation to extreme conditions
Archives of Microbiology, rok: 2020, ročník: 202, vydání: 3, DOI
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Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4(+)CD25(+)FoxP3(+) regulatory T cells activation
THERANOSTICS, rok: 2020, ročník: 10, vydání: 2, DOI
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Spatial structure of permafrost and active layer from the James Ross Island, Antarctica: Geological and Microbiological Insights
Rok: 2020, druh: Konferenční abstrakty
2019
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Analysis of gene expression in CD26+ CML leukemic stem cell population.
Rok: 2019, druh: Konferenční abstrakty
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Bioinformatic pipelines for whole transcriptome sequencing data exploitation in leukemia patients with complex structural variants
PeerJ, rok: 2019, ročník: 7, vydání: JUN, DOI
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Detection and functional analysis of TP53 mutations in CLL
Methods in Molecular Biology - Chronic Lymphocytic Leukemia: Methods and Protocols, rok: 2019, počet stran: 20 s.
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Drug Penetration Analysis in 3D Cell Cultures Using Fiducial-Based Semiautomatic Coregistration of MALDI MSI and Immunofluorescence Images
Analytical Chemistry, rok: 2019, ročník: 91, vydání: 21, DOI
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Flavobacterium circumlabens sp. nov. and Flavobacterium cupreum sp. nov., two psychrotrophic species isolated from Antarctic environmental samples.
Systematic and Applied Microbiology, rok: 2019, ročník: 42, vydání: 3, DOI
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MUNI Open Day
Rok: 2019, druh: Popularizační texty
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T cell receptor repertoire in systemic anaplastic large cell lymphoma.
Rok: 2019, druh: Konferenční abstrakty