Bilateral elevation of TNFa and IL-6 mRNAs in dorsal root ganglia alongside neuroaxis following unilateral nerve injury

Brázda,  Václav; Klusáková,  Ilona; Hradilová Svíženská,  Ivana; Dubový,  Petr

Bilateral elevation of TNFa and IL-6 mRNAs in dorsal root ganglia alongside neuroaxis following unilateral nerve injury

Warning

This publication doesn't include Faculty of Economics and Administration. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors	BRÁZDA Václav KLUSÁKOVÁ Ilona HRADILOVÁ SVÍŽENSKÁ Ivana DUBOVÝ Petr
Year of publication	2011
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Cytokines are injury-induced inflammatory mediators that contribute to both induction and maintenance of neuropathic pain. We used in situ hybridization and quanitative RT-PCR to provide evidence that unilateral chronic constriction injury (CCI) of the sciatic nerve induces synthesis of TNFa and IL-6 in DRG of different spinal cord segments alongside neuroaxis.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.