Fluorine Labeling as a Versatile Tool for Probing Nucleic Acid Folding and Interactions by NMR Spectroscopy

Warning

This publication doesn't include Faculty of Economics and Administration. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.

Authors	ZLÍNSKÁ Vladimíra MATOUSEK Vaclav TRANTÍREK Lukáš RIGO Riccardo
Year of publication	2022
Type	Article in Periodical
Magazine / Source	ALDRICHIMICA ACTA
MU Faculty or unit	Central European Institute of Technology
Citation
Web	https://www.sigmaaldrich.com/CZ/en/collections/aldrichimica-acta
Keywords	F-19 NMR spectroscopy; F-19 probes; DNA; RNA; F-19-labeling approaches; nucleic acid folding; nucleic acid/small molecule interactions; nucleic acid/protein interactions; in vitro; in vivo
Description	This mini-review provides an overview of approaches to F-19-labeling of nucleic acids. A special attention is paid to applications of F-19-labeled nucleic acids to resolve their polymorphism and characterize their folding and interactions with ligands and proteins in vitro and in living cells by using NMR spectroscopy.
Related projects:	Atomically resolved in vivo NMR spectroscopy as a novel tool for biological testing of therapeutically important genomic non-canonical DNA targets and their interactions with drugs in phenotypically diversified cancer cells. MSCAfellow4@MUNI