Fluorine Labeling as a Versatile Tool for Probing Nucleic Acid Folding and Interactions by NMR Spectroscopy

• Autoři: ZLÍNSKÁ Vladimíra; MATOUSEK Vaclav; TRANTÍREK Lukáš; RIGO Riccardo
• Rok publikování: 2022
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: ALDRICHIMICA ACTA
• Fakulta / Pracoviště MU: Středoevropský technologický institut
• www: https://www.sigmaaldrich.com/CZ/en/collections/aldrichimica-acta
• Klíčová slova: F-19 NMR spectroscopy; F-19 probes; DNA; RNA; F-19-labeling approaches; nucleic acid folding; nucleic acid/small molecule interactions; nucleic acid/protein interactions; in vitro; in vivo
• Popis: This mini-review provides an overview of approaches to F-19-labeling of nucleic acids. A special attention is paid to applications of F-19-labeled nucleic acids to resolve their polymorphism and characterize their folding and interactions with ligands and proteins in vitro and in living cells by using NMR spectroscopy.

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