Project information
Development of new diagnostic teniques for oncology
- Project Identification
- IBS5004010
- Project Period
- 1/2000 - 1/2004
- Investor / Pogramme / Project type
-
Academy of Sciences of the Czech Republic
- Programme of Targeted Research and Development Support
- MU Faculty or unit
- Faculty of Informatics
- Cooperating Organization
-
Institute of Biophysics
- Responsible person doc. RNDr. Stanislav Kozubek, DrSc.
The project is directed to the improvement of diagnostic techniques in oncology both in primary diseases and in related infections. The development of high-resolution cytometric techniques and methods of the detection of the telomerase activity will be the goals of the project. Topographic characteristics of appropriate genetic loci in selected tumour tissues will be mesured and correlated to tumour characteristcs. The development of techniques and methods for clinical applications will be followed by industrial development of a confocal cytometr. In addition, methods of detection of the telomerase activity and expresion will be optimised both for the diagnostic purposes, and for testing the sensitivity of cultured tumor cells to cytostatics and potential cytostatic agents. The improvement of diagnostic techniques of fungal infections typical of oncological patients will be the additional goal of the project. DNA probes will be prepared for clinica diagnostics.
Publications
Total number of publications: 55
2002
-
Nuclear structure and gene activity in human differentiated cells
Journal of Structural Biology, year: 2002, volume: 139, edition: 2
-
Optimisation of FISH Methodology for the Study of 3D Structure of Cell Nuclei Using Micro Axial Tomography
Biophysics of the Genome and Its Interactions, year: 2002
-
Structure of the human genome: Experimental results and models
Biophysics of the genome and its interactions, year: 2002
-
The 3D structure of human chromosomes in cell nuclei
Chromosome Research, year: 2002, volume: 10, edition: 7
-
Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology
Phil. Trans. R. Soc. Lond. B, year: 2002, volume: roč. 357, edition: April
-
Topography of genetic elements of X-chromosome relative to the cell nucleus and to the chromosome X territory determined for human lymphocytes
Gene, year: 2002, volume: 292, edition: 1
2001
-
Combined confocal and wide-field high-resolution cytometry of FISH-stained cells
Cytometry, year: 2001, volume: 45, edition: 1
-
Cytogenetics of Retinoblastoma
Year: 2001, type: Conference abstract
-
Exchange aberrations among 11 chromosomes of human lymphocytes induced by gamma-rays
International Journal of Radiation Biology, year: 2001, volume: 77, edition: 4
-
Higher-order chromatin structure of human granulocytes
Chromosoma, year: 2001, volume: 110, edition: 5