Project information
Development of new diagnostic teniques for oncology
- Project Identification
- IBS5004010
- Project Period
- 1/2000 - 1/2004
- Investor / Pogramme / Project type
-
Academy of Sciences of the Czech Republic
- Programme of Targeted Research and Development Support
- MU Faculty or unit
- Faculty of Informatics
- Cooperating Organization
-
Institute of Biophysics
- Responsible person doc. RNDr. Stanislav Kozubek, DrSc.
The project is directed to the improvement of diagnostic techniques in oncology both in primary diseases and in related infections. The development of high-resolution cytometric techniques and methods of the detection of the telomerase activity will be the goals of the project. Topographic characteristics of appropriate genetic loci in selected tumour tissues will be mesured and correlated to tumour characteristcs. The development of techniques and methods for clinical applications will be followed by industrial development of a confocal cytometr. In addition, methods of detection of the telomerase activity and expresion will be optimised both for the diagnostic purposes, and for testing the sensitivity of cultured tumor cells to cytostatics and potential cytostatic agents. The improvement of diagnostic techniques of fungal infections typical of oncological patients will be the additional goal of the project. DNA probes will be prepared for clinica diagnostics.
Publications
Total number of publications: 55
2003
-
Dual-color real-time telomeric repeat amplification protocol
BioTechniques, year: 2003, volume: 35, edition: 5
-
Changes in Telomerase Activity, Expression and Splicing in Response to Differentiation of Normal and Carcinoma Colon Cells
Anticancer Research, year: 2003, volume: Neuveden, edition: 23
-
Chromosomal territory segmentation in apoptotic cells
Cellular and Molecular Life Sciences, year: 2003, volume: 60, edition: 5
-
Improving measurement precision using automated micro-axial tomography
Biophysics of the Genome, year: 2003
-
Multilevel Adaptive Thresholding and Dual Simplex Mesh Deformation as a Tool for Tissue Reconstruction
Visualization, Imaging, and Image Processing, year: 2003
-
Nuclear and territorial topography of chromosome telomeres in human lymphocytes
Experimental Cell Research, year: 2003, volume: 289, edition: 1
-
Precise 3D image alignment in micro-axial tomography
Journal of Microscopy, year: 2003, volume: 209, edition: 2
-
Proč je biologie telomer, ač módní, přesto užitečná?
XXVII. Brněnské onkologické dny, year: 2003
-
Spherical Object Reconstruction Using Simplex Meshes from Sparse Data
Discrete Geometry for Computer Imagery, year: 2003
-
Tissue image reconstruction: Localization of nuclei markers and segmentation based on deformable models
Biophysics of the Genome, year: 2003