Project information
Molecular mechanisms of the cell proliferation and differentiation
- Project Identification
- GD204/08/H054
- Project Period
- 1/2008 - 12/2011
- Investor / Pogramme / Project type
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Czech Science Foundation
- Doctor grants
- MU Faculty or unit
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Faculty of Science
- prof. RNDr. Jan Šmarda, CSc.
- prof. RNDr. Jiří Fajkus, CSc.
- doc. RNDr. Lenka Fajkusová, CSc.
- doc. RNDr. Jan Hejátko, Ph.D.
- doc. Mgr. Ctirad Hofr, Ph.D.
- Mgr. Jakub Horák, Dr. rer. nat.
- RNDr. Lubomír Janda, Ph.D.
- doc. RNDr. Jaromír Marek, Ph.D.
- doc. Mgr. Jan Paleček, Dr. rer. nat.
- prof. RNDr. Jana Šmardová, CSc.
- prof. RNDr. Renata Veselská, Ph.D., M.Sc.
- Mgr. Pavlína Zatloukalová, Ph.D.
- prof. RNDr. Zbyněk Zdráhal, Dr.
- Other MU Faculty/Unit
- Faculty of Informatics
- Keywords
- regulation of cell proliferation and differentiation, genomics and proteomics, plant, animal and microbial models, bioinformatics
Plants and animals evolved significantly different strategies of regulation of the cell proliferation and differentiation. Identification and comparison of molecular mechanisms driving those different strategies in plants, animals and microorganisms might contribute to the identification of their common principles. The project is based on collaboration of laboratories involved in the study of the processes of the cell proliferation and differentiation in those different model organisms including human beings. Collaboration of the laboratories with expertise in (i) molecular plant physiology, (ii) molecular mechanisms maintaining the genome stability, (iii) proliferation, differentiation and programmed cell death of cancer cells and (iv) bioinformatics will result into a multidisciplinary, while still functional team that will guarantee successful solution of scheduled tasks. Participation of multiple, recently collaborating laboratories including Core lab will allow effective employment of high-throughput instrumentation in the planned genomics and proteomics approaches.
Publications
Total number of publications: 87
2008
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Telomere repeat binding protein variants show distinct kinetics and energetic nature of DNA-protein interaction
Year: 2008, type: Conference abstract
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The effects of TGFb proteins on osteoclast differentiation
Proceedings of the abstracts of the 13th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine, year: 2008
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The identification of cells with cancer stem cell phenotype in osteosarcomas.
Year: 2008, type: Conference abstract
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The identification of cells with cancer stem cell phenotype in pediatric solid tumors.
XIX. Biologické dny - Biologický výzkum pro lidské zdraví. Program a sborník abstrakt., year: 2008
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The influence of LOX/COX inhibitors on the ATRA induced differentiation in neuroblastoma cell lines.
International Journal of Mol. Medicine 22 (Sup. 1) - the 13th World Congress on Advances in Oncology and the 11th International Symposium on Molecular Medicine., year: 2008
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Vliv LOX/COX inhibitorů na ATRA indukovanou diferenciaci na modelu neuroblastomových a meduloblastomových buněčných linií.
Sborník abstraktů a přednášek - 18. konference dětských hematologů a onkologů České a Slovenské republiky, year: 2008
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v-Myb suppresses phorbol ester- and modifies retinoic acid-induced differentiation of human promonocytic U937 cells
Neoplasma, year: 2008, volume: 55, edition: 4