Project information
Structural biophysics of macromolecules

Information

This project doesn't include Faculty of Economics and Administration. It includes Faculty of Science. Official project website can be found on muni.cz.

Project Identification

GD204/03/H016

Project Period

1/2003 - 12/2006

Investor / Pogramme / Project type

Czech Science Foundation

Doctor grants

MU Faculty or unit

Faculty of Science

prof. RNDr. Viktor Brabec, DrSc.
prof. RNDr. Jaroslav Koča, DrSc.

Keywords

DNA, proteins, structure, cancer, antitumor drugs

The major objective of this project is to support, coordinate and make more effective scientific and research activities within the doctoral study program in the field of molecular biophysics and biology. Realization of this project will result incoordin ated activities within this doctoral study program of two research institutions in Brno with related and complementary scientific orientations in the fields of molecular biophysics and biology, namely the Faculty of Sciences of the MasarykUniversity - Na tional Center for Biomolecular Research and Institute of Biophysics, Academy of Sciences of the Czech Republic. A broader methodological orientation of the students participating in this project will be made possible by the use ofcomplementary and excell ent methodologies and instrumentation for research focused on the studies of structure of biomacromolecules and their interactions with the aid of the methods of molecular biophysics and biology.

Publications

Total number of publications: 40

2011

Comparison of protein structural motifs – challenges and algorithms. Improved approach and case studies

SVOBODOVÁ VAŘEKOVÁ Radka SEHNAL David PRAVDA Lukáš OPPELT Jan IONESCU Crina-Maria GEIDL Stanislav KOČA Jaroslav

Conference abstract

Year: 2011, type: Conference abstract
Docking study of matrix metalloproteinase inhibitors

RYŠKA Jan MISHRA Sushil Kumar SVOBODOVÁ VAŘEKOVÁ Radka KOČA Jaroslav

Conference abstract

Year: 2011, type: Conference abstract
Fast methods of atomic charge calculation: the Electronegativity Equalization Method for proteins.

IONESCU Crina-Maria SVOBODOVÁ VAŘEKOVÁ Radka SEHNAL David SKŘEHOTA Ondřej KOČA Jaroslav

Conference abstract

Year: 2011, type: Conference abstract
Predicting pKa values of substituted phenols from atomic charges.

GEIDL Stanislav SVOBODOVÁ VAŘEKOVÁ Radka SKŘEHOTA Ondřej KUDERA Michal IONESCU Crina-Maria SEHNAL David BOUCHAL Tomáš KOČA Jaroslav

Conference abstract

Year: 2011, type: Conference abstract
QSPR modeling – algorithms, challenges and IT solutions

SKŘEHOTA Ondřej SVOBODOVÁ VAŘEKOVÁ Radka GEIDL Stanislav KUDERA Michal SEHNAL David IONESCU Crina-Maria BOUCHAL Tomáš KOČA Jaroslav

Conference abstract

Year: 2011, type: Conference abstract

2010

Why acetylcholinesterase reactivators do not work in butyrylcholinesterase

WIESNER Jiří KŘÍŽ Zdeněk KUČA Kamil JUN Daniel KOČA Jaroslav

Article in Periodical

Journal of Enzyme Inhibition and Medicinal Chemistry, year: 2010, volume: 25, edition: 3

2009

Understanding the NMR Chemical Shifts for 6-halopurines: Role of Structure, Solvent, and Relativistic Effects

STANDARA Stanislav MALIŇÁKOVÁ Kateřina MAREK Radek MAREK Jaromír HOCEK Michal STRAKA Michal VAARA Juha

Article in Proceedings

Modeling Interactions in Biomolecules IV, year: 2009

2008

Mechanism of Hydrogen Bond Array Isomerization in Tetrahydroxycalix[4]arene and Tetrahydroxythiacalix[4]arene

MATOUŠEK Jiří ČAJAN Michal KULHÁNEK Petr KOČA Jaroslav

Article in Periodical

Journal of Physical Chemistry A, year: 2008, volume: 112, edition: 1
P-31 Chemical Shift Tensors in Nucleic Acids from the Quantum Chemistry Point of View

PRECECHTELOVA Jana PADRTA Petr MUNZAROVA Marketa SKLENÁŘ Vladimír

Article in Proceedings

23rd NMR Valtice, year: 2008

2007

Acetylcholinesterases - the similarities and differences

WIESNER Jiří KŘÍŽ Zdeněk KUČA Kamil JUN Daniel KOČA Jaroslav

Article in Periodical

Journal of Enzyme Inhibition and Medicinal Chemistry, year: 2007, volume: 22, edition: 4