Protein enginnering of mannosidase
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| Year of publication | 2012 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | N-Acetyl-D-mannosamine (ManNAc) is often used as a precursor in the chemical or enzymatic synthesis of the neuraminic acids found in glycolipids and glycoproteins. ManNAc is also a synthetic intermediate for a number of carbohydrate-derived families of biologically active compounds and pharmaceutical candidates. The main goal of this work is to produce N-acetyl-mannosaminidase via mutagenesis of mannosidase and to employ it in enzymatic synthesis of compounds containing ManNAc. |
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