MOLEonline 2.0: Interactive Web-based Analysis of Biomacromolecular Channels

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This publication doesn't include Faculty of Economics and Administration. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.
Authors

BERKA Karel HANÁK Ondřej SEHNAL David BANÁŠ Pavel NAVRÁTILOVÁ Veronika JAISWAL Deepti IONESCU Crina-Maria SVOBODOVÁ VAŘEKOVÁ Radka KOČA Jaroslav OTYEPKA Michal

Year of publication 2012
Type Article in Periodical
Magazine / Source Nucleic Acids Research
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://nar.oxfordjournals.org/content/40/W1/W222.full
Doi http://dx.doi.org/10.1093/nar/gks363
Field Physical chemistry and theoretical chemistry
Keywords CYTOCHROMES P450; PROTEIN STRUCTURES; NUCLEIC-ACIDS; SUBSTRATE PREFERENCES; POTASSIUM CHANNEL; PHOTOSYSTEM-II; ACTIVE-SITES; IDENTIFICATION; TUNNELS; MACROMOLECULES
Description Biomolecular channels play important roles in many biological systems, e.g. enzymes, ribosomes and ion channels. This article introduces a web-based interactive MOLEonline 2.0 application for the analysis of access/egress paths to interior molecular voids. MOLEonline 2.0 enables platform-independent, easy-to-use and interactive analyses of (bio)macromolecular channels, tunnels and pores. Results are presented in a clear manner, making their interpretation easy. For each channel, MOLEonline displays a 3D graphical representation of the channel, its profile accompanied by a list of lining residues and also its basic physicochemical properties. The users can tune advanced parameters when performing a channel search to direct the search according to their needs. The MOLEonline 2.0 application is freely available via the Internet at http://ncbr.muni.cz/mole or http://mole.upol.cz.
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