Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation

Krejčí,  Pavel; Aklian, Anie; Kaucká Petersen,  Markéta; Ševčíková,  Eva; Medalová,  Jiřina; Mikolka,  Pavol; Bálek,  Lukáš; Kubíčková,  Tereza; Renzová,  Tereza; Bryja,  Vítězslav; Veselá,  Iva; Kozubík,  Alois; Weis, MaryAnn; Paznekas, W.A.; Wolf, J.H.; Gutkind, J.S.; Wilcox, W.A.; Wnag Jabs, E.; Salazar, Lisa; Mašek, Jan Kukla

Receptor tyrosine kinases activate canonical WNT/beta catenin signaling via MAP kinase/LRP6 pathway and direct beta-Catenin phosphorylation

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Authors	KREJČÍ Pavel AKLIAN Anie KAUCKÁ Markéta ŠEVČÍKOVÁ Eva PROCHÁZKOVÁ Jiřina MIKOLKA Pavol BÁLEK Lukáš POSPÍŠILOVÁ Tereza SPOUSTOVÁ Tereza BRYJA Vítězslav VESELÁ Iva KOZUBÍK Alois WEIS MaryAnn PAZNEKAS W.A. WOLF J.H. GUTKIND J.S. WILCOX W.A. WNAG JABS E. SALAZAR Lisa MAŠEK Jan Kukla
Year of publication	2012
Type	Article in Periodical
Magazine / Source	Plos One
MU Faculty or unit	Faculty of Science
Citation
Doi	http://dx.doi.org/10.1371/journal.pone.0035826
Field	Physiology
Keywords	Receptor tyrosin kinase; Wnt/beta catenin; MAPK; LRP6
Description	Receptor tyrosine kinase signaling cooperates with WNT/beta catenin signaling in regulating many biological processes, but the mechanisms of their interaction remain poorly defined. We describe a potent activation of WNT/beta catenin by FGFR2 FGFR3, EGFR and TRKA kinases, which is independent of the PI3K/Akt pathway and it depends on ERK-MAPK mediated phospohrylation of WNT co-receptor LRP6.
Related projects:	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies Podpora výzkumné činnosti studentů v oblasti fyziologie a imunologie živočichů.