Clinicopathological correlations of nestin expression in surgically resectable pancreatic cancer including an analysis of perineural invasion

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Authors

LENZ Jiří KARÁSEK Petr JARKOVSKÝ Jiří MÚČKOVÁ Katarína DÍTĚ Petr KALA Zdeněk VESELSKÁ Renata HERMANOVÁ Markéta

Year of publication 2011
Type Article in Periodical
Magazine / Source Journal of Gastrointestinal and Liver Diseases
MU Faculty or unit

Faculty of Medicine

Citation
Field Other medical specializations
Keywords Pancreatic cancer; nestin; prognostic factor; perineural invasion.
Description An intimate link of nestin to biological process of pancreatic cancer was confirmated. The expression of nestin did not prove to be valuable prognostic factor and an immunohistochemical assesment of nestin expression is not superior to conventional prognostic factors in PDAC. A correlation between nestin expression in tumor cells and PNI was not confirmed and expression of nestin in nerve fibres of both PDAC and CP tissues seems to reflect the process of neural remodeling responsible for pancreatic neuropathy.
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