CYP2D6 phenotyping in clinical practice: serum or urine dextromethorphan/dextrorphan metabolic ratio?

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Authors

JUŘICA Jan BARTEČEK Richard PINDUROVÁ Eva ZENDULKA Ondřej KAŠPÁREK Tomáš ŠULCOVÁ Alexandra

Year of publication 2011
Type Article in Proceedings
Conference 17th International Conference on Cytochrome P450
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords CYP2D6; phenotype
Description The aim of this work was to elucidate if CYP2D6 phenotyping by evaluation of molar dextromethorphan to dextrorphan metabolic ratio (MRDEM/DOR) in serum has the usability and reliability as the assessment of MRDEM/DOR in urine. We measured MRDEM/DOR in serum and CYP2D6 genotype in 51 drug-naive patients and investigated cut-off value for discrimination of poor metabolizers from extensive and intermediate ones. The correlation of serum MRDEM/DOR with urine MRDEM/DOR in 30 healthy volunteers was analysed in parallel.
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