Enhancement of psychostimulant effect and development of behavioural sensitisation to methamphetamine in mice by combined treatment with piracetam

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Authors

MÁCHALOVÁ Alena ŠLAIS Karel VRŠKOVÁ Dagmar ŠULCOVÁ Alexandra

Year of publication 2011
Type Article in Periodical
Magazine / Source Activitas Nervosa Superior Rediviva
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords methamphetamine; piracetam; behavioural sensitisation; mice; open field test
Description Piracetam in our experiment enhanced acute effects of methamphetamine as well as development of sensitisation to its stimulatory effects. Background of these pharmacological drug-drug interactions remains unclear. Although clinically piracetam itself shows minimal adverse effects and toxicity, its combination with methamphetamine could worsen the negative drug abuse consequences.
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