MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia

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Authors	VARGOVÁ Karin CURIK Nikola BURDA Pavel BAŠOVÁ Petra KULVAIT Vojtěch POSPÍŠIL Vít SAVVULIDI Filipp KOKAVEC Juraj NEČAS Emanuel BERKOVÁ Adéla OBRTLÍKOVÁ Petra KARBAN Josef MRÁZ Marek POSPÍŠILOVÁ Šárka MAYER Jiří TRNĚNÝ Marek ZAVADIL Jiří STOPKA Tomáš
Year of publication	2011
Type	Article in Periodical
Magazine / Source	Blood
MU Faculty or unit	Central European Institute of Technology
Citation
Doi	http://dx.doi.org/10.1182/blood-2010-05-285064
Field	Oncology and hematology
Keywords	MYB; CLL; miR-155 host gene; B-CLL
Description	Elevated levels of microRNA miR-155 represent a candidate pathogenic factor in chronic B-lymphocytic leukemia (B-CLL). In this study, we present evidence that MYB (v-myb myeloblastosis viral oncogene homolog) is overexpressed in a subset of B-CLL patients. MYB physically associates with the promoter of miR-155 host gene (MIR155HG, also known as BIC, B-cell integration cluster) and stimulates its transcription. This coincides with the hypermethylated histone H3K4 residue and spread hyperacetylation of H3K9 at MIR155HG promoter. Our data provide evidence of oncogenic activities of MYB in B-CLL that include its stimulatory role in MIR155HG transcription.
Related projects:	Funkční a strukturní změny microRNA u lymfoproliferativních malignit a jejich vliv na prognózu onemocnění a predikci léčebné odpovědi