Correlation of gene expression with centrosome amplification in multiple myeloma

Investor logo

Warning

This publication doesn't include Faculty of Economics and Administration. It includes Faculty of Medicine. Official publication website can be found on muni.cz.
Authors

ŠEVČÍKOVÁ Sabina KRYUKOV Fedor DEMENTYEVA Elena Vladimirovna NĚMEC Pavel HÁJEK Roman

Year of publication 2011
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Centrosome amplification (CA) may lead to genomic instability of malignant plasma cells in multiple myeloma (MM). Study objective was to evaluate association of CA with expression of genes controlling centrosome duplication. In this study, we showed close interaction between presence of CA and expression of genes controlling centrosome duplication (PCNT, AURKB, AURKA, CCNB2, PLK4, HMMR, TACC3). Some of these genes (AURKA, PCNT and TACC3) reflect even CA positivity of patients.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.