The Overexpression of Cathepsin D Senzitizes Brest Cancer Cells to TRAIL-induced Apoptosis

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Authors

JANČEKOVÁ Blanka BENEŠ Petr ONDROUŠKOVÁ Eva ŠMARDA Jan

Year of publication 2011
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description Tumor cells have often impaired classical caspase-dependent apoptosis pathway and may be therefore more sensitive to agents that trigger alternative cell death pathways. Targeting lysosomes represents a method of choice as many human tumors have increased levels of lysosomal proteases. The lysosomal permeabilization pathway therefore offers a therapeutic window between cancer cells and normal tissue. TRAIL represents an anti-cancer therapeutic that can induce both classical and lysosomal apoptotic signaling. The lysosomal aspartic protease cathepsin D (cath-D) acts as mediator of induced-apoptosis by various chemotherapeutics. It has been suggested that cath-D can alter apoptosis pathways in enzymatic activity-dependent and independent manner. We conclude that Cath-D sensitizes breast carcinoma cells MDA-MB-231 to TRAIL-induced apoptosis in enzymatic activity-dependent manner.
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