Effect of perphenazine on electrogram of rat isolated heart
| Authors | |
|---|---|
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Acta Veterinaria Brno |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.2754/avb201180010087 |
| Field | Physiology |
| Keywords | Phenothiazines; Langendorff heart; QT-interval; Arrhythmia |
| Description | The aim of this study was to clarify whether administration of antipsychotic perphenazine contributes to the electrophysiological changes of the isolated heart. Fourteen adult male Wistar rats were divided into two groups. Langendorff hearts were perfused with Krebs-Henseleit solution at constant pressure (85 mmHg). The electrogram was recorded by touch-free method. The hearts of the first group were exposed to 3.10-5 M perphenazine, the hearts of the second group to 3.10-8 M perphenazine. The incidence of arrhythmias and the heart rate and QT interval changes were studied on electrogram during 30 min periods of control, the first perphenazine administration, washout, and the second drug administration. Perphenazine administration significantly prolonged QT and QTc in group 1. In group 2, QT and QTc prolongation was less pronounced. A number of arrhythmias appeared, from single premature ventricular complexes to more severe ones in both groups. The heart rate changes were non-significant. |
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