Matrix metalloproteinases.

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Authors

ZÍTKA Ondřej KUKAČKA Jiří KŘÍŽKOVÁ Soňa HÚSKA Dalibor ADAM Vojtěch MASAŘÍK Michal PRŮŠA Richard KIZEK René

Year of publication 2010
Type Article in Periodical
Magazine / Source Current Medicinal Chemistry
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords matrix metalloproteinases; collagen; tissue inhibitors of matrix metalloproteinases; cysteine switch; zinc; metallothionein; tumour disease
Description Matrix metalloproteinases (MMPs), also known as matrixins, belong to a group of zinc-dependent proteins, which are thought to play a central role in the breakdown of extracellular matrix. Collagen, elastin, gelatine and casein are major components cleaved by MMPs. The breakdown of these components is essential for many physiological processes such as embryonic development, morphogenesis, reproduction, and tissue resorption and remodelling. MMPs also participate in pathological processes such as arthritis, cancer, cardiovascular and neurological diseases. This review summarizes current knowledge regarding these proteins, their participation in physiological and pathophysiological roles, their involvement in activation and inhibition, and their interactions with other metal-binding proteins including metallothioneins.
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