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Title in English Zinc and its relation to prostate tumours
Authors

GUMULEC Jaromír MASAŘÍK Michal HRABEC Roman ROVNÝ Arne BINKOVÁ Hana BABULA Petr ADAM Vojtěch KIZEK René

Year of publication 2010
Type Article in Periodical
Magazine / Source Praktický lékař
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.prolekare.cz/prakticky-lekar-clanek?id=32567
Field Oncology and hematology
Keywords zinc;metallothionein;thiols;resistance;tumour disease
Description Zinc ions (Zn2+) are essential elements necessary for the normal function of mammalian cells. They participate in the regulation of the immune system, gene expression, energy metabolism, signal transduction and perform a structural function. However, an increased level of these ions is toxic, and so needs to be controlled. This control is primarily carried out by zinc transporters and zinc-binding proteins, in particular, metallothioneins. Prostatic tissue is very specific in Zn2+metabolism. Its cells accumulate a greater quantity of these ions (up to ten times more). Prostate cancer, a common cancer of men, is characterized by diverse and not very clear mechanisms, which serve to maintain Zn2+ levels. This unusual metabolism of Zn2+ has two important implications: -participation in the pathogenesis of the disease (due to apoptosis) and - increased serum levels of metallothioneins (with potential use of these proteins as markers for this disease).
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