Generation of myeloma-specific T cells using dendritic cells loaded with MUC1- and hTERT- drived nonapeptides or myeloma cell apoptotic bodies

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Authors

OČADLÍKOVÁ Darina KRYUKOV Fedor MOLLOVÁ Klára KOVÁŘOVÁ Lucie BUREŠOVÁ Ivana MATĚJKOVÁ Eva PENKA Miroslav BÜCHLER Tomáš HÁJEK Roman MICHÁLEK Jaroslav

Year of publication 2010
Type Article in Periodical
Magazine / Source Neoplasma
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords multiple myeloma; dendritic cells; immunotherapy; hTERT; MUC1; apoptotic bodies
Description The aim of our study was to generate myeloma-specific cytotoxic T lymphocytes in vitro using dendritic cells loaded with peptide antigens or apoptotic bodies. We present a method for the priming and expansion of myeloma-specific T lymphocytes using dendritic cells loaded with different types of tumor antigens. Cytotoxic T lymphocytes and/or activated dendritic cells generated by the described methods can be applied for cellular immunotherapy against multiple myeloma and other malignancies.
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