Generation of myeloma-specific T cells using dendritic cells loaded with MUC1- and hTERT- drived nonapeptides or myeloma cell apoptotic bodies

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Authors	OČADLÍKOVÁ Darina KRYUKOV Fedor MOLLOVÁ Klára KOVÁŘOVÁ Lucie BUREŠOVÁ Ivana MATĚJKOVÁ Eva PENKA Miroslav BÜCHLER Tomáš HÁJEK Roman MICHÁLEK Jaroslav
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Neoplasma
MU Faculty or unit	Faculty of Medicine
Citation
Field	Oncology and hematology
Keywords	multiple myeloma; dendritic cells; immunotherapy; hTERT; MUC1; apoptotic bodies
Description	The aim of our study was to generate myeloma-specific cytotoxic T lymphocytes in vitro using dendritic cells loaded with peptide antigens or apoptotic bodies. We present a method for the priming and expansion of myeloma-specific T lymphocytes using dendritic cells loaded with different types of tumor antigens. Cytotoxic T lymphocytes and/or activated dendritic cells generated by the described methods can be applied for cellular immunotherapy against multiple myeloma and other malignancies.
Related projects:	University Research Centre - Czech Myeloma Group Buněčná imunoterapie s využitím různých nádorových antigenů u mnohočetného myelomu