www.rnaworkbench.com: A new program for analyzing RNA interference

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Authors	SVOBODOVÁ VAŘEKOVÁ Radka BRADÁČ Ivan PLCHÚT Martin ŠKRDLA Michal WACENOVSKY Michael MAHR Helmuth MAYER Georg TANNER Herbert BRUGGER Hermann WITHALM Josef LEDERER Peter HUBER Heinrich GIERLINGER Gerhard GRAF Ronald TAFER Hakim HOFACKER Ivo SCHUSTER Peter POLCIK Martin
Year of publication	2008
Type	Article in Periodical
Magazine / Source	Computer Methods and Programs in Biomedicine
MU Faculty or unit	Faculty of Science
Citation
Field	Physical chemistry and theoretical chemistry
Keywords	RNA interference; siRNA design; mRNA secondary structures; siRNA sequence rules
Description	RNA interference (RNAi) has become an important tool to study and utilize gene silencing by introducing short interfering RNA (siRNA). In order to predict the most efficient siRNAs, a new software tool, RNA Workbench (RNAWB), has been designed and is freely available (after registration) on http://www.rnaworkbench.com. In addition to the standard selection rules, RNAWB includes the possibility of statistical analyses of the applied selection rules (criteria). The role of RNA secondary structures in the RNA interference process as well as the application of sequence rules are discussed to show the applicability of the software.
Related projects:	Biomolecular centre