Nestin expression in human tumors and tumor cell lines

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Authors

KRUPKOVÁ Olga LOJA Tomáš ZAMBO Iva VESELSKÁ Renata

Year of publication 2010
Type Article in Periodical
Magazine / Source Neoplasma
MU Faculty or unit

Faculty of Science

Citation
Field Oncology and hematology
Keywords nestin; intermediate filaments; cytoskeleton; human tumors; angiogenesis; cancer stem cells
Description The aim of this review is to summarize current knowledge on nestin expression in human tumors and corresponding tumor cell lines, as well as recent findings on the intracellular localization of nestin in human tumor cells, especially with regard to the possible correlation between nestin expression and the malignant phenotype of transformed cells. Nestin expression in vascular endothelial cells during angiogenesis is also reviewed. Special attention is paid to the detection of nestin in cancer stem cells.
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