Rad52 Sumoylation Affects the Efficiency of the Recombination and DNA Repair

• Authors: ALTMANNOVÁ Veronika; ECKERTBOULET Nadine; ARNERIC Milica; KOLESÁR Peter; ZHAO Xiaolan; LISBY Michael; KREJČÍ Lumír
• Year of publication: 2009
• Type: R&D Presentation
• MU Faculty or unit: Faculty of Science
• Description: Homologous recombination (HR) plays a vital role in DNA metabolic processes including meiosis, DNA repair, DNA replication, and maintenance of rDNA homeostasis. Defects in HR can lead to pathological outcomes, including genetic diseases and cancer. Recent studies suggest that the post-translational modification by small ubiquitin-like modifier (SUMO) protein plays an important role in mitotic and meiotic recombination but its precise function is still unclear. We will present the characterization of the novel effect of SUMOylation on the properties of Saccharomyces cerevisiae mediator protein Rad52.

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