A118G polymorphism of OPRM1 gene is associated with schizophrenia

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Authors

ŠERÝ Omar PŘIKRYL Radovan ČASTULÍK Lukáš ŠŤASTNÝ František

Year of publication 2010
Type Article in Periodical
Magazine / Source Journal of Molecular Neuroscience
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords schizophrenia association study polymorphism OPRM1 DNA
Description Schizophrenia is ranked among multifactor diseases in whose pathogenesis, besides environmental factors, an interplay of functional polymorphisms of a larger number of candidate genes is involved. Neurodevelopmental abnormities are among the most accepted hypotheses in the etiology of schizophrenia. Recently, the role of oligodendrocytes in the development of the cortex has been cited repeatedly. During their various phases of differentiation oligodendrocytes present on their surfaces diverse receptors, among others the opioid receptor (OPRM1). The study was focused on the relationship between the functional A118G polymorphism of the OPRM1 gene (rs1799971) and schizophrenia in a groups of 130 male patients and 452 male controls. An association study revealed yet unpublished statistically significant difference of allelic and genotypic frequencies between the control and patient groups.
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