Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum.
| Authors | |
|---|---|
| Year of publication | 2009 |
| Type | Article in Periodical |
| Magazine / Source | Journal of Medical Microbiology |
| MU Faculty or unit | |
| Citation | |
| web | http://jmm.sgmjournals.org/cgi/reprint/58/6/832?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=Matejkova&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT |
| Field | Microbiology, virology |
| Keywords | penicillin-G benzathine; azithromycin resistance; clinical specimens; isolate; PCR |
| Description | We report an occurrence of treatment failure after oral spiramycin therapy in a man with secondary syphilis and a reported penicillin and tetracycline allergy. Molecular detection revealed treponemal DNA in the blood of the patient and sequencing of the 23S rDNA identified an A to G transition at the gene position corresponding to position 2059 in the Escherichia coli 23S rRNA gene. The occurrence of this novel 23S rDNA mutation was examined among 7 rabbit-propagated syphilitic strains of Treponema pallidum and among 22 syphilis patient isolates from the Czech Republic. The prevalence of A2058G and A2059G mutations among clinical specimens was 18.2 and 18.2 %, respectively. |
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