CHROMATIN ASSOCITED HMGB1 PROTEIN IS INVOLVED IN REGULATION OF TELOMERE LENGTHS IN PLANTS

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Authors

PROCHÁZKOVÁ SCHRUMPFOVÁ Petra GRASSER Klaus FAJKUS Jiří

Year of publication 2009
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description High Mobility Group (HMG) proteins type B bind local DNA structures, promote DNA bending and interact with factors of the transcription, repair and recombination machineries. Arabidopsis thaliana genome encodes 7 HMGB proteins which differ in structure, expression pattern and DNA-binding properties. We observe that HMGB1 takes part in telomere maintenance. Plants lacking HMGB1 display telomere shortening and, consistently, overexpression of HMGB1 leads to telomere elongation.
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