Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes

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Authors	BÉBAROVÁ Markéta MATEJOVIČ Peter PÁSEK Michal JANSOVÁ Dagmar ŠIMURDOVÁ Milena NOVÁKOVÁ Marie ŠIMURDA Jiří
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Naunyn-Schmiedebergs Archives of Pharmacology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Physiology
Keywords	perphenazine; antipsychotic drug; sodium current; transient outward current; rat ventricular myocytes
Description	Perphenazine reversibly blocked fast sodium current INa (reducing its amplitude; IC50 = 1.24 microM) and transient outward potassium current Ito (accelerating its apparent inactivation with a slight decrease of its amplitude; IC50 = 38.2 microM, evaluated from changes of the time integral). Both blocks were use- and frequency-dependent at 3.3 Hz. Computer simulations suggest that perphenazine interacts preferentially with INa channels in inactivated states and with Ito channels in both open and open-inactivated states.
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