Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes

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Authors

BÉBAROVÁ Markéta MATEJOVIČ Peter PÁSEK Michal JANSOVÁ Dagmar ŠIMURDOVÁ Milena NOVÁKOVÁ Marie ŠIMURDA Jiří

Year of publication 2009
Type Article in Periodical
Magazine / Source Naunyn-Schmiedebergs Archives of Pharmacology
MU Faculty or unit

Faculty of Medicine

Citation
Field Physiology
Keywords perphenazine; antipsychotic drug; sodium current; transient outward current; rat ventricular myocytes
Description Perphenazine reversibly blocked fast sodium current INa (reducing its amplitude; IC50 = 1.24 microM) and transient outward potassium current Ito (accelerating its apparent inactivation with a slight decrease of its amplitude; IC50 = 38.2 microM, evaluated from changes of the time integral). Both blocks were use- and frequency-dependent at 3.3 Hz. Computer simulations suggest that perphenazine interacts preferentially with INa channels in inactivated states and with Ito channels in both open and open-inactivated states.
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