SYNTHESIS OF NEW 1-SUBSTITUTED 4-(2-PHENYLQUINAZOLIN-4-YL)- AND 4-(2-PHENYLQUINAZOLIN-4-YLIDENE) THIOSEMICARBAZIDES

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Authors	MOHAMED Walid Fathalla PAZDERA Pavel
Year of publication	2008
Type	Article in Periodical
Magazine / Source	Chemistry of Heterocyclic Compounds
MU Faculty or unit	Faculty of Science
Citation
Field	Organic chemistry
Keywords	quinazoline; thiosemicarbazide; domino reaction; hydrogen bond interaction
Description	Two new 1-substituted 4-(2-phenylquinazolin-4-yl)- and 4-(2-phenylquinazolin-4-ylidene) thio-semicarbazides were formed by a multistep domino reaction of imidoyl isothiocyanate derivative with 1,1-di-R-hydrazine in acetone solution. Application of hydrazine hydrate under the same reaction conditions afforded 4-(2-phenylquinazolin-4(3H)-ylidene)-2-(propen-2-yl)-1-(propan-2-ylidene) thio-semicarbazide via a six-step triple-component domino reaction.
Related projects:	New catalysts and reagents for sustainable green syntheses and combinatorial syntheses