Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines.

• Authors: VESELSKÁ Renata; HERMANOVÁ Markéta; LOJA Tomáš; CHLAPEK Petr; ZAMBO Iva; VESELÝ Karel; ZITTERBART Karel; ŠTĚRBA Jaroslav
• Year of publication: 2008
• Type: Article in Periodical
• Magazine / Source: BMC Cancer
• MU Faculty or unit: Faculty of Science
• Web: http://www.biomedcentral.com/1471-2407/8/300
• Field: Oncology and hematology
• Keywords: nestin; CD133; intermediate filaments; osteosarcoma; immunocytochemistry; immunohistochemistry; cancer stem cells
• Description: Immunohistochemical and immunocytochemical methods demonstrate the expression of nestin, the intermediate filament protein class VI, in osteosarcomas. Osteosarcoma cell lines showing nestin+/CD133+ phenotype were successfully derived from these tumors.

Related projects

• Molecular basis of cell and tissue regulations
• Diagnostický a prediktivní význam molekulárně cytogenetických markerů u embryonálních nádorů dětského věku
• Molecular mechanisms of the cell proliferation and differentiation