Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines.

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Authors

VESELSKÁ Renata HERMANOVÁ Markéta LOJA Tomáš CHLAPEK Petr ZAMBO Iva VESELÝ Karel ZITTERBART Karel ŠTĚRBA Jaroslav

Year of publication 2008
Type Article in Periodical
Magazine / Source BMC Cancer
MU Faculty or unit

Faculty of Science

Citation
Web http://www.biomedcentral.com/1471-2407/8/300
Field Oncology and hematology
Keywords nestin; CD133; intermediate filaments; osteosarcoma; immunocytochemistry; immunohistochemistry; cancer stem cells
Description Immunohistochemical and immunocytochemical methods demonstrate the expression of nestin, the intermediate filament protein class VI, in osteosarcomas. Osteosarcoma cell lines showing nestin+/CD133+ phenotype were successfully derived from these tumors.
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