Elimination Voltammetry of Oligonucleotides

Trnková,  Libuše; Mikelová,  Radka; Jelen, František; Adam,  Vojtěch; Kizek,  René

Elimination Voltammetry of Oligonucleotides

Warning

This publication doesn't include Faculty of Economics and Administration. It includes Faculty of Science. Official publication website can be found on muni.cz.

Authors	TRNKOVÁ Libuše MIKELOVÁ Radka JELEN František ADAM Vojtěch KIZEK René
Year of publication	2008
Type	Article in Proceedings
Conference	Electrochemistry of Nucleic Acids and Proteins. Book of Abstracts
MU Faculty or unit	Faculty of Science
Citation
Field	Electrochemistry
Keywords	oligonucleotide; voltammetry; EVLS
Description	EVLS can be considered as a mathematical model of the transformation of current-potential curves capable of eliminating some selected current components, while conserving others by means of elimination functions. The present contribution summarizes applications of EVLS to the study of oligonucleotides (ODNs) with different sequences of cytosine (C) and adenine (A). The EVLS offers a new tool for very good resolution of A and C in ODNs, and, thus, for a qualitative and quantitative sensing of changes in primary structure of ODN chains.
Related projects:	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) Utilization of Hyphenated Electrochemical Methods to the Study of Electrochemical and Bio-electrochemical Processes at Solid-Electrolyte Interfaces New approaches in electrochemical analysis of nucleic acids and oligonucleotides aimed at a ultrasensitive microdetection of DNA and DNA hybridization Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine