The association of MMP-9 and IL-18 gene promoter polymorphisms with gingivitis in adolescent

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Authors	VOKURKA Jan KLAPUŠOVÁ Lucie PANTUCKOVA Pavla KUKLETOVÁ Martina KUKLA Lubomír IZAKOVIČOVÁ HOLLÁ Lydie
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Arch Oral Biol
MU Faculty or unit	Faculty of Medicine
Citation
Field	ORL, ophthalmology, stomatology
Keywords	gingivitis; gene; polymorphism; IL-18; MMP; interleukin
Description	Interleukin 18 (IL-18) is shown to be a proinflammatory cytokine that regulates the expression of matrix metalloproteinase 9 (MMP-9). The aim of this study was to test for differences between Czech adolescents with and without gingivitis in relation to MMP-9 and IL-18 polymorphisms. The -1562 T allele of MMP-9 gene could have a role in gingivitis in adolescents. In addition, interaction of the MMP-9 and IL-18 genes could be considered a risk factor for the development of gingivitis in children.
Related projects:	Dental research centre Analýza polymorfizmů v genech prozánětlivých a remodelačních faktorů ve vztahu k imunitní reakci a klinickému stavu pacientů s parodontitidou