Capillary Microreaction Method Development for Drug Discovery Support

Pelcová,  Marta; Konečný,  Jiří; Glatz,  Zdeněk; Hoogmartens, Jos; Van Schepdael, Ann

Capillary Microreaction Method Development for Drug Discovery Support

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Authors	ZEISBERGEROVÁ Marta KONEČNÝ Jiří GLATZ Zdeněk HOOGMARTENS Jos VAN SCHEPDAEL Ann
Year of publication	2008
Type	Article in Proceedings
Conference	Book of Abstracts 22nd International Symposium on MicroScale Bioseparations and Methods for Systems Biology
MU Faculty or unit	Faculty of Science
Citation
Field	Biochemistry
Keywords	drug metabolism; microsomes; cytochrome P450; EMMA; microreaction
Description	The presented EMMA method could be integrated in preliminary studies at first stage of drug discovery. This method could help to screen new drug candidates. There is no need for radiolabeling, minimal sample preparation and consumption and thus it can speed up data throughput and decrease the operational costs.
Related projects:	Proteins in metabolism and interaction of organisms with the environment Capillary electrophoresis as a tool for the drug-metabolism studies Integrované bioanalytické technologie pro mikroanalýzy a diagnostiku s využitím LIF a hmotnostní spektrometrie