Synthesis of New 1-Substituted-4-(2-phenylquinazolin-4-yl and 4-ylidene) Thiosemicarbazide
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Proceedings |
| Conference | 11th INTERNATIONAL ELECTRONIC CONFERENCE ON SYNTHETIC ORGANIC CHEMISTRY |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.usc.es/congresos/ecsoc/11/ECSOC11.htm |
| Field | Organic chemistry |
| Keywords | quinazoline; thiosemicarbazide; domino reaction; hydrogen bond interaction |
| Description | Two new 1-substituted-4-(2-phenylquinazolin-4-yl and 4-ylidene) thiosemicarbazides 3 and 5 were formed by multistep domino reaction of imidoyl isothiocyanate derivative 1 with 1,1-di-R hydrazine in acetone solution. Applied hydrazine hydrate under the same reaction condition afforded 4-(2-phenylquinazolin-4(3H)-ylidene)-2-(prop-1-en-2-yl)-1- (propan-2-lidene) thiosemicarbazide (7) via six step three component domino reaction. Compounds 3, 5 and 7 were identified by CHNS elemental analysis, 1H-NMR, 13C-NMR spectral data and their correlation with ones from known structural motives. |
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