High affinity lectins from human opportunistic pathogens: structure/function studies

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Authors

WIMMEROVÁ Michaela LAMEIGNERE Emilie MALINOVSKÁ Lenka SABIN Charles ADAM Jan POKORNÁ Martina VARROT Annabelle MITCHELL Edward P. IMBERTY Anne

Year of publication 2007
Type Article in Proceedings
Conference XIX International Symposium on Glycoconjugates
MU Faculty or unit

Faculty of Science

Citation
Field Biochemistry
Keywords lectin; pathogen; x-ray structure; calorimetry
Description The complementary techniques of binding experiments, isothermal titration microcalorimetry, surface plasmon resonance and high resolution X-ray crystallography were used to decipher the thermodynamical and structural basis for the unusually high affinity binding of these lectins to their host carbohydrates. In addition, site-directed mutagenesis in combination with structural and functional studies was used to understand the roles of particular amino acids in the fine definition of sugar specificity and preference.
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