Spectroscopic and Theoretical Insights into Sequence Effects of Aminofluorene-Induced Conformational Heterogeneity and Nucleotide Excision Repair

• Authors: MENENI Srinivasa; SHELL Steven; GAO Lan; JURECKA Petr; LEE Wang; SPONER Jiri; ZOU Yue; CHIARELLI Paul; CHO Bongsup
• Year of publication: 2007
• Type: Article in Periodical
• Magazine / Source: Biochemistry
• MU Faculty or unit: Faculty of Science
• Field: Physical chemistry and theoretical chemistry
• Keywords: nucleotide; HPLC; NMR; CD; MD simulations; QM calculations
• Description: A systematic spectroscopic and computational study was conducted in order to probe the influence of base sequences on stacked (S) versus B-type (B) conformational heterogeneity induced by the major dG adduct derived from the model carcinogen 7-fluoro-2-aminofluorene (FAF).

Related projects

• Proteins in metabolism and interaction of organisms with the environment
• Biomolecular centre