Co-Expression by Keratinocytes of Migration Stimulating Factor (MSF) and a Functional Inhibitor of its Bioactivity (MSFI)

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Authors

JONES Sarah FLORENCE Margaret ELLIS Ian KAŇKOVÁ Kateřina SCHOR Seth SCHOR Ana

Year of publication 2007
Type Article in Periodical
Magazine / Source Experimental Cell Research
MU Faculty or unit

Faculty of Medicine

Citation
Field Genetics and molecular biology
Keywords MSF; NGAL; lipocalin; keratinocytes; fibroblasts; HaCat
Description Data presented in this communication indicate that MSF is constitutively expressed by keratinocytes in culture, but is rendered functionally inactive by the co-secretion of an inhibitor (MSFI). This inhibitor was identified as NGAL. MSFI activity was found in NGAL obtained from four different sources: keratinocytes, neutrophils and recombinant protein isolated from both procaryotic and eucaryotic sources. This is a novel activity of NGAL which does not seem to be mediated by previously reported mechanisms, such as iron transport or direct protein-protein binding.
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