Haplotype analysis of NADPH oxidase p22phox gene in Czech patients with bronchial asthma

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Authors

IZAKOVIČOVÁ HOLLÁ Lydie KAŇKOVÁ Kateřina JURAJDA Michal ZNOJIL Vladimír

Year of publication 2007
Type Article in Proceedings
Conference ICMI 2007
MU Faculty or unit

Faculty of Medicine

Citation
Field Immunology
Keywords haplotype; NADPH oxidase; asthma; polymorphism; gene
Description In this study, we sought to eliucidate the role of genetic variability in the NADPH oxidase gene in asthma susceptibility by means of association study of three polymorphisms (SNPs) in the CYBA (cytochrome b(-245) alpha) gene (16q24.3) encoding p22phox subunit of NADPH oxidase. Our study supports hypothesis that genetic variability in the CYBA gene probably contributes to the susceptibility to the bronchial asthma (or its related phenotypes) in the Czech population.
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