Relationship between parameters of cell-mediated immunity, oxidative stress and head and neck squamous cell carcinoma
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Proceedings |
| Conference | Book of abstracts from the conference Synthetic and natural compounds in cancer therapy and prevention. |
| MU Faculty or unit | |
| Citation | |
| Field | Biochemistry |
| Keywords | head and neck cell carcinoma; oxidative stress; cell-mediated immunity |
| Description | Oxidative stress, alterations in host immunity and inflammation may contribute to genesis and progression of head and neck squamous cell carcinoma (HNSCC). We investigated relationships between malondialdehyde (MDA) as a marker of lipid peroxidation and parameters of activated macrophages, i.e. tumor necrosis factor alpha as a marker of inflammation and neopterin as a marker of cell-mediated immunity and clinical stage of HNSCC. Our results confirm the role of activated macrophages and the cellular immune system in HNSCC. In patients with activated T-lymphocytes, levels of TNF alpha inversely reflected the prognosis of disease. Although production of MDA in HNSCC patients is normal, it seems that activated T-lymphocytes contribute to lipid peroxidation. |
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