Optimization of solid-phase extraction using artificial neural networks in combination with experimental design for determination of resveratrol by capillary zone electrophoresis in wines

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Authors

SPANILÁ Miroslava PAZOUREK Jiří FARKOVÁ Marta HAVEL Josef

Year of publication 2005
Type Article in Periodical
Magazine / Source J. Chromatogr. A.
MU Faculty or unit

Faculty of Informatics

Citation
Field Analytic chemistry
Keywords Solid-phase extraction; Artificial neural networks; Experimental design; Single variable approach; Multivariable approach; Capillary electrophoresis; trans-resveratrol
Description Solid-phase extraction (SPE) is often used for preconcentration of analytes from biological samples. Such an analytical step requires optimization for obtaining reliable results. Optimization in analytical chemistry is traditionally still often done with relaxation method, when an optimal value of a single variable is searched for (single variable approach, SVA). Nowadays, using artificial neural networks (ANN) as a multivariable approach (MVA) in optimization is rapidly expanding. In this work, the optimization of SPE using relaxation method (SVA) and optimization by ANN in combination with experimental design (MVA) are compared and the latter approach is practically illustrated. Advantages of MVA over SVA for optimization are discussed. The prediction of the optimal SPE conditions for determination cis- and trans-resveratrol in Australian wines by capillary zone electrophoresis is described and the improvement of efficiency of SPE using MVA is confirmed.
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