Jun: the master regulator in healthy and cancer cells
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | Journal of Applied Biomedicine |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | AP-1; Jun; cancer; apoptosis; cell cycle; differentiation |
| Description | Healthy cells strictly regulate gene transcription to control crucial cellular regulatory pathways. Members of the Jun protein family, c-Jun, JunB, and JunD are key subunits of the transcription factor AP-1 that controls transcription from various gene promoters. The genes targeted by Jun affect essential life processes, such as cell cycle progression, differentiation or programmed cell death. Therefore, the loss of proper Jun function is often associated with cancer. This review summarizes recent advances in understanding of function of the Jun proteins in healthy and cancer cells. |
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