VPLYV POHLAVIA NA BIOTRANSFORMÁCIU DEXTROMETORFANU, FENACETÍNU A TOLBUTAMIDU V PREKLINICKOM EXPERIMENTE

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Title in English The influence of gender on metabolic activity of enzymatic system of cytochrome P450 in the model of isolated perfused rat liver.
Authors

ZAHRADNÍKOVÁ Lucia ZENDULKA Ondřej JUŘICA Jan HADAŠOVÁ Eva

Year of publication 2006
Type Article in Proceedings
Conference Jubilejní 50. studentská vědecká konference. Program a abstrakta.
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords Cytochróm P-450; vplyv pohlavia; model izolovanej perfundovanej pečene
Description We studied the influence of gender on selected isoenzymes using the following drugs as specific markers: tolbutamide for CYP2C6, dextromethorphan for CYP2D2, phenacetin for CYP1A2 and nifedipine for CYP3A4. CYP2D2 activity in rat females was significantly higher than in males. Also the final concentration of a marker metabolite (dextrorphan) in females was higher only in CYP2D2. The elevation was 10% in the 60th min and 9% in the 120th min. In contrast activity in CYP subfamily in females was lower than in males. All last three isoforms of CYP450, CYP2C6 (tolbutamid), CYP1A2 (phenacetin) and CYP3A4 (nifedipine), showed lower activity when compared to CYP2D2, and female metabolization rate was slower than in males.
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