VPLYV POHLAVIA NA BIOTRANSFORMÁCIU DEXTROMETORFANU, FENACETÍNU A TOLBUTAMIDU V PREKLINICKOM EXPERIMENTE

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Title in English The influence of gender on biotransformation of dextromethorphan, phenacetine and tolbutamide in preclinic experiment
Authors

ZAHRADNÍKOVÁ Lucia JUŘICA Jan ZENDULKA Ondřej DOSTÁLEK Miroslav HADAŠOVÁ Eva

Year of publication 2006
Type Article in Proceedings
Conference Psychiatrie
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords gender; cytochrome P450; the model of isolated perfused liver
Description As we expected, the activity of CYP subfamilies differed due to gender. CYP 2D2 activity in rat females was significantly higher than in males. Also the final concentration of a marker metabolite (dextrorphan) in females was higher only in CYP 2D2. The elevation was 5,7% in the 30th min, 33% in the 60th min and 34% in the 120th min. In contrast activity in CYP 3A subfamily in females was lower than in males. Next two isoforms of CYP450, used as markers were tolbutamid (CYP2C6 – metabolite 4-hydroxytolbutamid) and phenacetin (CYP1A2 – metabolite paracetamol). They showed dramatically lower activity when compared to CYP 2D2, and female metabolization was slower than in males. Thus, the obtained results suggest that the activity of CYP 450 is gender dependent and different dosing schemes for males and females should be used when administering drugs metabolized by CYP 450.
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