VPLYV POHLAVIA NA BIOTRANSFORMÁCIU DEXTROMETORFANU, FENACETÍNU A TOLBUTAMIDU V PREKLINICKOM EXPERIMENTE
| Title in English | The influence of gender on biotransformation of dextromethorphan, phenacetine and tolbutamide in preclinic experiment |
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| Authors | |
| Year of publication | 2006 |
| Type | Article in Proceedings |
| Conference | Psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | gender; cytochrome P450; the model of isolated perfused liver |
| Description | As we expected, the activity of CYP subfamilies differed due to gender. CYP 2D2 activity in rat females was significantly higher than in males. Also the final concentration of a marker metabolite (dextrorphan) in females was higher only in CYP 2D2. The elevation was 5,7% in the 30th min, 33% in the 60th min and 34% in the 120th min. In contrast activity in CYP 3A subfamily in females was lower than in males. Next two isoforms of CYP450, used as markers were tolbutamid (CYP2C6 – metabolite 4-hydroxytolbutamid) and phenacetin (CYP1A2 – metabolite paracetamol). They showed dramatically lower activity when compared to CYP 2D2, and female metabolization was slower than in males. Thus, the obtained results suggest that the activity of CYP 450 is gender dependent and different dosing schemes for males and females should be used when administering drugs metabolized by CYP 450. |
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