Antioxidant and DNA reparation enzyme genetic polymorphism as a pathogenic factor of diabetic nephropathy
| Authors | |
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| Year of publication | 2006 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Catalase is an endogenous antioxidant enzyme neutralizing hydrogen peroxide and is induced by oxidative challenge. A -262C/T polymorphism in the promoter region of the gene is a functional variant modulating activity of the enzyme. Ascertained association suggests that variability in the CAT gene may confer a modest genetic risk for the development of diabetic nephropathy in type 2 diabetics in Czech population. |
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