Korelace zvýšeného oxidativního stresu s negativní prognózou u spinocelulárního karcinomu hlavy a krku
| Title in English | Correlation between oxidative stress and negative prognosis in HNSCC |
|---|---|
| Authors | |
| Year of publication | 2006 |
| Type | Article in Proceedings |
| Conference | Sborník přednášek, 69. kongres České společnosti otorinolaryngologie a chirurgie hlavy a krku |
| MU Faculty or unit | |
| Citation | |
| Field | ORL, ophthalmology, stomatology |
| Keywords | oxidative stress; head neck squamous cell carcinoma; superoxide dismutase |
| Description | Introduction: Reactive oxygen species play an important role in head and neck squamous cell carcinoma (HNSCC) due to known ethiologic causality of alcohol and smoking in HNSCC development as major sources of oxidative stress. Our aim is to investigate relationship between genetic variants encoding for manganese superoxidedismutase (MnSOD); activity of the expressed enzyme and clinical stage of HNSCC. Material and Methods: We included 65 patients with HNSCC in period of July 2004 to June 2005. We estimeted genetic variants of MnSOD polymorphism Ala16Val, activity of MnSOD in plasma (p-SOD), in red blood cells (erc-SOD) and malondialdehyde (MDA) and tumor necrosis factor alpha (TNF) levels. Results: Val/Val variant manifested higher TNF than other two variants (p<0.05). Increased plasmatic MDA was found in patients with recurrent disease (p<0.05). Patients with negative neck (N0) had lower pSOD activity than those with locoregional metastatic spread (N+) (p<0.0005). Activity of ercSOD and plasmatic level of MDA tended to increase in N+ with no significant difference. Conclusion: Val/Val homozygotes manifesting higher TNF level offers an interpretation that they were genetically predisposed to increased sensitivity to conditions leading to TNF elevation, what includes oxidative stress. Increased oxidative burden leading to elevation of MDA was found in recurrent disease and in patients with N+. SOD is predisposed to become a prognostic factor in HNSCC since it is significantly increased in N+ patients. Our results suggest that increased MDA and SOD levels at the time of initial surgery for HNSCC might be considered as a prognostic factor of early relapse. |
| Related projects: |