The effects of posttranslational modifications on function of the Bcl-2 protein

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Authors	ZAHRADNÍČKOVÁ Eva VAŇKOVÁ Jana MACEČKOVÁ Vendula ŠMARDA Jan
Year of publication	2006
Type	Article in Periodical
Magazine / Source	Chemické listy
MU Faculty or unit	Faculty of Science
Citation
Field	Genetics and molecular biology
Keywords	Bcl-2; apoptosis; cell differentiation; phosphorylation
Description	BM2 monoblasts overexpressing Bcl-2 exhibit low viability, condensed chromatin, nuclear fragmentation and DNA fragmentation. Our results suggest that the Bcl-2 protein undergoing post-translational modification by phosphorylation cannot interact with its protein partners thus loosing its capability to suppress apoptosis.
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