Extáze zvyšuje plachost a snižuje agresivitu v sociálních interakcích myší

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Title in English	MDMA increases timidity and decreases agressivity in social interactions in mice
Authors	ŠLAIS Karel LANDA Leoš ŠULCOVÁ Alexandra
Year of publication	2005
Type	Article in Periodical
Magazine / Source	Československá fyziologie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	MDMA; agonistic interactions; mice; behavioural study; anxiety; anxiogenic effects
Description	We analyzed behavioural changes in 15 acts of 4 categories: sociable, timid, aggressive and locomotor. Mice were administered MDMA at the doses of 2.5 or 10 or 30 mg/kg, or saline in the equal amount of 1ml/kg, orally. Paired interactions were videotaped and ethological analysis was performed. In aggressive mice, MDMA in all tested doses caused highly significant inhibition of all aggressive activities with the significant increase of sociability and defensive-escape behaviour and at the highest dose also of walking. In timid mice, the most significant changes were in increase of defensive-escape behaviour and decrease of sociable activities; just the highest dose stimulated significantly walking.
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