Extracellular diffusion parameters during and after unilateral carotid occlusion in rat
| Authors | |
|---|---|
| Year of publication | 2005 |
| Type | Article in Proceedings |
| Conference | Sborník abstrakt 5. konference České neurovědecké společnosti |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | diffusion; ischemia; carotid occlusion; stroke |
| Description | Measurements of the ECS diffusion parameters in the brain have shown that a decreases and l increases during global cerebral ischemia, but there is a lack of information about the ECS parameters during hypoxia-ischemia and in the post-ischemic period after unilateral carotid occlusion. The observed post-ischemic increase in a and decrease in l suggest that extrasynaptic communication between neurons and glia is altered during the post-ischemic period. Moreover, the concentrations of neuroactive substances, metabolites and applied drugs may be altered and could play an important role in the recovery process from stroke. |
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