Gender differences in sensitization to methamphetamine effects on locomotion in rats

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Authors

HANESOVÁ Mariana LANDA Leoš ŠLAIS Karel ŠULCOVÁ Alexandra

Year of publication 2005
Type Article in Periodical
Magazine / Source Homeostasis in Health and Diseases
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords gender differences; behavioural sensitization; methamphetamine; rats
Description On the contrary to results of previous study realized in mice, in rats on the same dosage regimen a phenomenon of behavioural sensitization to methamphetamine stimulatory effects on locomotion was not confirmed. Instead, with the exception on the Day 21 in females, a significant dose dependent decrease (tolerance) of distance run appeared following the repeated drug treatment and female rats displayed a greater tolerance than males did.
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